![]() People who developed CVST or HIT after first dose of AstraZeneca vaccine ![]() Providers were advised to allow an interval of at least 1 week before administering the AstraZeneca vaccine to give time for anticoagulation therapy to stabilise. If a patient had a thromboembolic event, as for any acute illness, providers were advised to delay vaccination until the patient was clinically well. These treatments may have worsened the clinical course of TTS. Patients with suspected TTS were advised not to be given any heparin or platelet transfusions. There was no evidence that exposure to heparin increased the risk of developing TTS.Ī patient could be given heparin after an AstraZeneca vaccine is administered, and vice versa. ![]() Advice for health professionals Heparin treatment and the AstraZeneca vaccine Some people with pre-existing conditions were preferred not to have AstraZeneca for their first or second dose. People under the age of 60 years were preferred to have an alternative vaccine to AstraZeneca. The risk of TTS was much lower after the second dose. TTS appeared to be more severe in younger women.Īlmost all reported cases of TTS occurred after the first dose of AstraZeneca. No biological or other risk factors were identified that predicted who developed TTS.Ĭases were reported in all ages, and in both men and women. This was likely due to increased detection due to increased awareness, as well as early diagnosis and treatment. The overall case fatality rate in Australia was lower than reported internationally. Some cases were relatively mild, some had significant morbidity, and some were fatal. about 2 per 100,000 people vaccinated with AstraZeneca aged 60 years or older.Ī range of severity of illness was reported in Australia.1 At that time, the rates of TTS were estimated to be: 1 In Australia, the last case of TTS reported by the Therapeutic Goods Administration was in December 2021. Patients were urged to seek urgent medical attention if they experienced any symptoms of TTS. unexplained pin-prick rash or bruising away from the injection site.severe, persistent headache that did not improve with regular painkillers.Symptoms typically occured between 4 and 42 days after a first dose of the AstraZeneca vaccine. People aged under 60 years were able to receive the AstraZeneca vaccine if the benefits outweighed the risks and they provided informed consent, such as during the outbreak of the Delta variant in 2022. The other COVID-19 vaccines are not associated with TTS. The risk of TTS was higher in younger people, so ATAGI preferred an alternative to AstraZeneca for people under 60 years of age. Blood clots can appear in different parts of the body such as the brain or abdomen (belly). TTS involves blood clotting (thrombosis) combined with low platelets (thrombocytopenia). ![]() There was a link between the AstraZeneca vaccine and a rare but serious side effect – thrombosis with thrombocytopenia syndrome (TTS). TTS can cause long-term disability and death. Thrombosis with thrombocytopenia syndrome (TTS) The following information remains for reference purposes. On 17 June 2021, ATAGI issued a statement recommending an alternative to AstraZeneca for those aged under 60 years. On 8 April 2021, the Australian Government received advice and recommendations from the Australian Technical Advisory Group on Immunisation (ATAGI) about the Vaxzevria (AstraZeneca) vaccine and a syndrome called Thrombosis with Thrombocytopenia Syndrome (TTS). Symptoms typically occurred between 4 and 42 days after a first dose of the AstraZeneca vaccine.ĪstraZeneca is no longer available in Australia from 21 March 2023, so no further cases of AstraZeneca-related TTS can occur in Australia. about 2 to 3 per 100,000 people vaccinated with AstraZeneca under 60 years of age.about 2 per 100,000 people vaccinated with AstraZeneca aged 60 years or older.In Australia, the rate of AstraZeneca-related TTS was estimated to be: There was a link between the AstraZeneca vaccine and a rare but serious side effect called thrombosis with thrombocytopenia syndrome (TTS). On this page AstraZeneca is no longer available in Australia
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